Did You Find The Cure For Hair Fall? A study found that a drug against epilepsy increases the density and thickness of hair. Depending on the age, staying peeled can be very traumatic.Hair has always had a very strong social and aesthetic connotation, both loss (known as alopecia) and hair growth. Undoubtedly, hair loss is a subject that goes beyond the aesthetic to be a health issue.
There are, as we know innumerable treatments some more effective than others to treat this problem that affects around 50% of men and between 5 and 10% of women, especially after 50 years. The percentage reaches 95% of the male population over 70 years. However, the final solution seems to be far from being found.
Therefore it is understood that these days there is a great stir among experts for the discovery of a novel treatment, based on a drug that is already used against epilepsy, which can cure baldness.
Indeed, a group of researchers from the University of Seoul, has just published in the journal Biomaterials a hopeful study on the efficacy of valproic acid (a medicine that is often used in the treatment of seizures and also against bipolar disorder) that, they observed, increases the density and thickness of hair. In the trial, they used a new system of dissolvable cellulose micro needles, which they have patented under the name of DMN.
There is a normal and expected daily fall. Every day we lose between 25 and 100 hairs since the follicles that make up the hair grow and renew permanently.
However, there is still no need to celebrate. Because many treatments tested in mice are not tested in humans.
“It would not be the first time that a promising drug in mice does not reach humans,“ Sergio Vañó, a member of the AEDV’s Tricology Group and director of the Trichology Unit and study.
The reason is that “the biology of the hair follicle of rodents is very different from ours.” Here we have the example of capillary cloning, for example: in 2003 it was successfully achieved in mice, but we are in 2018 and we still can not replicate it in humans, “Vañó.
Last year, another group of researchers from the University of Texas, studying the formation of nerve tumors and the role of the KROX20 protein in the development of nerves, found that if they killed the cells that produce this protein, the mice lost hair.
In addition, they could observe that the cells that produce KROX20 also manufactured another protein called SCF that is responsible for coloring the hair.
The loss of SCF makes us gray hair and the loss of KROX20 that we lose hair. So, do we have the cure in our hands? Again the same problem: it is a study in mice.
The work presented by the group from Seoul “is interesting because part of the evidence (although still scarce) that relates the topical use of valproic acid as a treatment for androgenetic alopecia,” explains Miguel Sánchez Viera, director of the Institute of Integral Dermatology (IDEI).
The great novelty are the biodegradable needles that were used to inject the drug. “There are still years of research to know if this hypothesis is confirmed or what its effectiveness is, because the first results indicate that only a slight improvement is achieved.” The most novel of his study, beyond the anti-epileptic drug, is the patent of those biodegradable micro needles that they have designed “,Sánchez Viera. But “it will be years until this new system goes to be tested in humans, to check their level of safety, non-toxicity and efficacy, depending on the necessary doses.”
The Seoul experiment has a point in favor: if a laboratory wants to invest in these microcapsules with the anticonvulsant substance for the treatment of alopecia, it has half done, since it is an approved drug, tested and marketed for use, by systemic way.
Valproic acid is widely known, including its toxicity (severe in pregnant women) and this will make it easier to reach the final stage beforehand, although the patented micro needles must also pass the rigorous controls of research and approval. This will allow the time of commercialization to be shortened and if its efficacy and safety in humans is proven. It may one day become a new and revolutionary treatment against baldness.
Even the most expensive anti-hair loss shampoo does not work, no matter what the advertising says. And, meanwhile, what options are available to deal with this problem? Experts warn: an anti-hair shampoo, even if obscenely expensive, will never work no matter what the advertising says. And low cost surgery, when it involves traveling to foreign clinics of dubious health, is not worth it either. Because this type of surgery for a hair transplant can lead to infections and scars.
The only thing that is scientifically proven against hair loss are medical treatments. Either topically, such as gels or lotions or orally or injectable. “So far the only approved and safe medications that are commonly used in clinical experience are minoxidil, which is a vasodilator, and drugs such as finasteride and dutasteride,” says Vañó.
“It is also working on treatments with low-power laser (which increases the arrival of oxygen and nutrients to the hair root), platelet-rich plasma (which is obtained from the patient’s own blood and, thanks to its proteins and stem cells, stimulates the creation of new hair and its growth), or acting on the WNT gene (responsible for the production of hair follicles), but there is still much to investigate.